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In this talk, I will give an overview on our vision on quantum computing with electron spin qubits, and discuss the progress and challenges in realizing fault-tolerant, fully integrated silicon quantum circuits [1, 2]. I will first present our work on characterizing gate fidelities, including the realization of a high-fidelity two-qubit gate that meets the requirement for implementing quantum error correction [3, 4, 5, 6]. Then I will steer the focus to quantum control of spin qubits using a cryo-CMOS chip, named "Horse Ridge", which is a first step towards solving the wiring issues at the quantum-classical interface [2, 7]. Finally, I will introduce our recent spin qubit experiments, in particular the realization of the first two-qubit logic between distant spins in silicon, which is achieved by using an on-chip superconducting resonator [8].